Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
Cell permeable: no
Reversible: no
Product does not compete with ATP.
Primary TargetPromotes tubulin depolymerization
General description
Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also available as a 50 mM solution in DMSO (Cat. No. 487929).
Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also acts as a high-affinity ligand for the cancer-related kinases ABL, c-KIT, BRAF, and MEK (Kd﹤2 µM).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Park, H., et al. 2011. Chem. Med. Chem.in press.Bunz, F., et al. 1998. Science 282, 1497.Fleischman, L.F., et al. 1993. Oncogene8, 771.Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun.189, 1429.Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci.103, 1167.
Packaging
10 mg in Plastic ampoule
Reconstitution
Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 year at -20°C.
Warning
Toxicity: Carcinogenic / Teratogenic (D)
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :