Non disponible en dehors du Royaume-Uni et de l'Irlande
General description
A cell-permeable Monastrol (Cat. No. 475879) analog with much enhanced potency and selectivity (over 8 other kinesins) in inhibiting mitotic kinesin Eg5-ATPase activity (IC50 = 1.17 vs. 20.73 µM for VS-83 and Monastrol, respectively) and in inducing monoasters formation (EC50 = 7.27 vs. 58.74 µM for BSC-1 cells treated with VS-83 and Monastrol, respectively). Shown to exhibit ≥10-fold antiproliferative activity than Monastrol against U-87 MG, U-118 MG, and U-373 MG glioblastoma cells.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Muller, C., et al. 2007. Cancer Chemother. Pharmacol.59, 157.Santamaria, A., et al. 2007. Mol. Biol. Cell18, 4024.Sarli, V., et al. 2005. ChemBioChem6, 2005.
Packaging
5 mg in Glass bottle
Packaged under inert gas
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Warning
Toxicity: Regulatory Review (Z)
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :