Calpastérol; humain ; réactif; domaine I

Non disponible en dehors du Royaume-Uni et de l'Irlande

Analysis Note

homogeneous by SDS-PAGE

Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary Targetcalpain-1

50 nM completely inhibits the activity of 7.5 µg/ml calpain I

General description

An endogenous protease inhibitor that acts specifically on Calpain I (Cat. No. 208712), a Ca²⁺-dependent cysteine protease. Widely distributed in mammalian and avian cells. Has better inhibitory action than Calpain Inhibitor I (Cat. No. 208719) and Calpain Inhibitor II (Cat. No. 208721). Calpastatin corresponds to domain I of human calpastatin. The inhibitory sequence of human domain I consists of at least 18 amino acid residues.

Domain I of human calpastatin. Endogenous protease inhibitor that acts specifically on Calpain-1 (Cat. No. 208712). Exhibits greater inhibitory potency than calpain inhibitors I and II.

Legal Information

Not available for sale in Japan.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Salamino, F., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1326.Uemori, T., et al. 1990. Biochem. Biophys. Res. Commun. 166, 1485.Asada, K., et al. 1989. J. Enzyme Inhib.3, 49.

Packaging

1 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)