Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
Reversible: no
Product does not compete with ATP.
Primary TargetA2PLA2
Cell permeable: yes
General description
Inhibits epinephrine-stimulated thromboxane production (86% at 3.5 µM) via inhibition of phospholipase A2 (PLA2) in human platelets. Also blocks glucose-induced insulin secretion in pancreatic islets. Possesses moderate leukotriene antagonist activity.
A cell-permeable inhibitor of phospholipase A2 that blocks epinephrine-stimulated thromboxane production in platelets. Inhibits ATP-stimulated phosphatidylcholine (PC) secretion in alveolar type II cells. Also blocks phorbol ester and A23187-induced PC secretion in type II cells. Reported to block glucose-induced insulin secretion by pancreatic β-cells. Exhibits moderate leukotriene antagonist activity.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Liu, L., et al. 1999. J. Cell. Biochem.72, 103.Simonsson, E., et al. 1998. Diabetes47, 1436.Konrad, R.J., et al. 1992. Biochim. Biophys. Acta1135, 215.Banga, H.S., et al. 1986. Proc. Natl. Acad. Sci. USA83, 9197.
Packaging
25 mg in Plastic ampoule
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Warning
Toxicity: Standard Handling (A)
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