Not available outside of the UK & Ireland.
Application
Research CategoryApoptosis & Cancer
Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Kallikrein 7/KLK7 in human kidney tissue and human bone marrow.
ELISA Analysis: A representative lot detected Kallikrein 7/KLK7 in ELISA applications (Shan, S.J., et. al. (2006). Clin Chem. 52(10):1879-86; Kishi, T., et. al. (2004). Clin Chem. 50(4):709-16).
Detect KLK7 using this mouse monoclonal Anti-Kallikrein 7/KLK7 Antibody, clone 73-1, Cat. No. MABC967. It was used in ELISA and Immunohistochemistry (Paraffin).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Kallikrein-7 (UniProt: P49862; also known as hK7, Serine protease 6, Stratum corneum chymotryptic enzyme, hSCCE) is encoded by the KLK7 (also known as PRSS6, SCCE) gene (Gene ID: 5650) in human. KLK7 is a member of the 15-member kallikrein subfamily of serine proteases. Human KLK7 displays 40 60% amino acid homology with other members of the family. Members of this family are involved in diverse physiological functions and serve as biomarkers for cancer. Increased expression of KLK7 is associated with unfavorable prognosis and progression of ovarian cancer. Less differentiated tumors of more advanced stage show higher level KLK7 expression. KLK7 has chymotrypsin-like activity and cleaves proteins with aromatic side chains in the P1 position. Its activity is inhibited by Zn2+ and Cu2+. KLK7 catalyzes the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. It is also reported to play a role in the activation of precursors to inflammatory cytokines.
Immunogen
A full length recombinant human pro-Kallikrein 7.
Other Notes
Concentration: Please refer to lot specific datasheet.
Physical form
Format: Purified
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Sodium bicarbonate buffer, pH 8.2 with 0.02% sodium azide.
Quality
Evaluated by Immunohistochemistry in human skin tissue.
Immunohistochemistry Analysis: A 1:250 dilution of this antibody detected Kallikrein 7/KLK7 in human skin tissue.
Specificity
Clone 73-1 specifically detects kallikrein 7 (KLK7) in human.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Target description
27.53 kDa calculated.
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