cis-4-Hydroxy-L-proline, collagen synthesis inhibitor

Code: h1637-250mg D2-231

Not available outside of the UK & Ireland.

Application

cis-4-Hydroxy-L-proline (CHP) is a proline analog that inhibits collagen synthesis and has been used as an anticancer compound. CHP blocked myotube forma...


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$333.86 250MG
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Not available outside of the UK & Ireland.

Application

cis-4-Hydroxy-L-proline (CHP) is a proline analog that inhibits collagen synthesis and has been used as an anticancer compound. CHP blocked myotube formation and expression of sarcomeric myosin heavy chain in C2C12 murine skeletal muscle cells. CHP inhibited proliferation of murine Panc02 pancreatic carcinoma cell line and rat pancreatic carcinoma cell line DSL6A.

Biochem/physiol Actions

cis-4-Hydroxy-L-proline (CHP) and its derivatives may have anticancer activity. cis-4-Hydroxy-L-proline and other hydrosyl-L-prolines are important intermediates for chiral synthesis of potential drugs.

Other Notes

Constituent of Amanita sp. peptide toxins but not of animal proteins like collagen.

application(s)peptide synthesis
assay≥98% (TLC)
colorwhite to faint yellow
formpowder
InChI keyPMMYEEVYMWASQN-IMJSIDKUSA-N
InChI1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4-/m0/s1
mp257 °C (dec.) (lit.)
Quality Level100
SMILES stringO[C@@H]1CN[C@@H](C1)C(O)=O
technique(s)ligand binding assay: suitable
Cas Number618-27-9
This product has met the following criteria to qualify for the following awards:



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