Epirubicin hydrochloride, >=90% (HPLC)

Name: Epirubicin hydrochloride, >=90% (HPLC)
Brand: SIGMA-ALDRICH
SKU: e9406-5mg
Price: 302.90 USD

Code: e9406-5mg D2-231

Not available outside of the UK & Ireland.

Application

Epirubicin is used to inhibit topoisomerase II and DNA helicase activity. Epirubicin is used to study metastatic breast cancerand cardiac toxicity.

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$302.90 5MG

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Not available outside of the UK & Ireland.
Application
Epirubicin is used to inhibit topoisomerase II and DNA helicase activity. Epirubicin is used to study metastatic breast cancerand cardiac toxicity.
Biochem/physiol Actions
Cell-permeable anthracycline antitumor antibiotic. Antineoplastic. A stereoisomer of doxorubicin that exhibits reduced cardiotoxicity. Its antitumor actions are mediated by targeting topoisomerase II.
Epirubicin is antimitotic and cytotoxic. It inhibits nucleic acid and protein synthesis. Epirubicin may do so by forming complexes with DNA and intercalation between base pairs, by inhibiting topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, and by preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.
Packaging
5, 10 mg in glass bottle

antibiotic activity spectrum neoplastics
assay ≥90% (HPLC)
biological source synthetic
color red to deep red
form powder
InChI key MWWSFMDVAYGXBV-FGBSZODSSA-N
InChI 1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22-,27-;/m0./s1
mode of action DNA synthesis | interferes, enzyme | inhibits
Quality Level 100
SMILES string Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
solubility H₂O: soluble
storage temp. −20°C

Safety Data Sheet
Safety Data Sheet for E9406-5MG
Certificate of Analysis
Sigma Certificate of Analysis

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Cas Number 56390-09-1

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Epirubicin hydrochloride, >=90% (HPLC)

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antibiotic activity spectrum	neoplastics
assay	≥90% (HPLC)
biological source	synthetic
color	red to deep red
form	powder
InChI key	MWWSFMDVAYGXBV-FGBSZODSSA-N
InChI	1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22-,27-;/m0./s1
mode of action	DNA synthesis \| interferes, enzyme \| inhibits
Quality Level	100
SMILES string	Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
solubility	H₂O: soluble
storage temp.	−20°C