Wedelolactone, >=98% (HPLC), solid

Code: w4016-1mg D2-231

Not available outside of the UK & Ireland.

Biochem/physiol Actions

Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Irreversible...


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$197.89 1MG
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Not available outside of the UK & Ireland.

Biochem/physiol Actions

Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Irreversible inhibitor of IKKα and β kinase activity (IC50 ﹤ 10 µM). Wedelolactone has no effects on p38 MAP kinase or Akt.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. W4016.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Packaging

1 mg in glass bottle

assay≥98% (HPLC)
colorwhite to brown
formpowder
InChI keyXQDCKJKKMFWXGB-UHFFFAOYSA-N
InChI1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3
Quality Level100
SMILES stringCOc1cc(O)c-2c(OC(=O)c3c-2oc4cc(O)c(O)cc34)c1
solubilityDMSO: 10 mg/mL, clear
storage temp.2-8°C
Cas Number524-12-9
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