SKF-96365, >=98% (HPLC), solid

Code: s7809-5mg D2-231

Not available outside of the UK & Ireland.

Application

SKF-96365 has been used as : a nonselective transient receptor potential 6 (TRPC6) blocker in human podocytes an antagonist of store-operated Ca2+ infl...


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Your Price
$302.90 5MG
REQUEST

Not available outside of the UK & Ireland.

Application

SKF-96365 has been used as : a nonselective transient receptor potential 6 (TRPC6) blocker in human podocytes an antagonist of store-operated Ca2+ influx in neuronsan inhibitor for transient receptor potential 3 (TRPC3) in mice

Biochem/physiol Actions

SKF-96365 with an alkylated imidazole ring is a selective inhibitor of receptor-mediated Ca2+entry and voltage-gated Ca2+entry . SKF-96365 mediated depolarization of smooth cardiac muscle membrane and had no impact on the acetylcholine (ACh)-induced depolarization. It is an inhibitor for SOCE (store-operated calcium entry). It also inhibits Homer1 protein expression. SKF-96365 elicits protective functionality in 1-methyl-4-phenylpyridinium(MPP) mediated cytotoxicity.

Packaging

5 mg in glass bottle

assay≥98% (HPLC)
colorwhite
formsolid
InChI keyFWLPKVQUECFKSW-UHFFFAOYSA-N
InChI1S/C22H26N2O3.ClH/c1-25-20-9-5-18(6-10-20)4-3-15-27-22(16-24-14-13-23-17-24)19-7-11-21(26-2)12-8-19;/h5-14,17,22H,3-4,15-16H2,1-2H3;1H
Quality Level100
SMILES stringCl.COc1ccc(CCCOC(Cn2ccnc2)c3ccc(OC)cc3)cc1
solubilityH2O: >20 mg/mL, DMSO: >20 mg/mL
Cas Number130495-35-1
This product has met the following criteria to qualify for the following awards:



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