Spiperone, solide

Name: Spiperone, solide
Brand: SIGMA-ALDRICH
SKU: s7395-250mg
Price: 242.32 USD

Code: s7395-250mg D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Spiperone was used to study the role of dopamine receptors in facilitating the male sexual behavior in quails.⁶

Spiperone has been used to block ...

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$242.32 250MG

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Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Spiperone was used to study the role of dopamine receptors in facilitating the male sexual behavior in quails.⁶

Spiperone has been used to block the actions of 5-hydroxytryptamine (5-HT) receptor. It also has been used to study its anti tumor effects in glioblastoma (GBM) cell lines.

Biochem/physiol Actions

Selective D₂ dopamine receptor antagonist; α_1B-adrenoceptor antagonist; mixed 5-HT_2A/5-HT₁ serotonin receptor antagonist; antipsychotic.

General description

Spiperone is a butyrophenone antipsychotic agent. It induces calcium-dependent chloride secretion in the airway and functions as a potential therapeutic target for cystic fibrosis.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. S7395.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Packaging

250 mg in glass bottle

Reconstitution

Solutions may be stored for 1-2 days at 4 °C.

color	light yellow
form	solid
Gene Information	human ... ADRA1B(147), DRD2(1813), DRD3(1814), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356)rat ... Adra1a(29412), Adra1b(24173), Adra1d(29413), Adra2a(25083), Drd1a(24316), Drd2(24318), Drd3(29238), Htr1a(24473), Htr2a(29595), Htr2c(25187), Htr7(65032)
InChI key	DKGZKTPJOSAWFA-UHFFFAOYSA-N
InChI	1S/C23H26FN3O2/c24-19-10-8-18(9-11-19)21(28)7-4-14-26-15-12-23(13-16-26)22(29)25-17-27(23)20-5-2-1-3-6-20/h1-3,5-6,8-11H,4,7,12-17H2,(H,25,29)
Quality Level	200
SMILES string	Fc1ccc(cc1)C(=O)CCCN2CCC3(CC2)N(CNC3=O)c4ccccc4
solubility	ethanol: 1.5 mg/mL, H₂O: slightly soluble 0.2 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2 mg/mL, 0.1 M HCl: slightly soluble 0.3 mg/mL

Safety Data Sheet for S7395-250MG
Certificat d'analyse Sigma

Cas Number

749-02-0

Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :

Spiperone, solide

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