SKF-83959 hydrobromide, >=98% (HPLC), solid

Not available outside of the UK & Ireland.

Application

SKF-83959 was used in dopamine signaling studies on eye blinking in monkeys and on phosphorylation of CaMKIIα in mice.

Biochem/physiol Actions

D₁ dopamine receptor agonist. Displays antagonist activity in vitro and agonist activity in vivo.

SKF-83959 is an atypical agonist of D₁ dopamine receptor and an allosteric modulator of σ-1 receptor on in brain and liver tissues. It has neuroprotective and anti-parkinsonian effects through selective activation of phosphoinositol-linked D₁ receptor and promotes migration of cultures astrocytes by ERK1/2 activation. In in vitro studies SKF-83959 exhibits antagonist activity against dopamine D₁ receptors coupled to adenylyl cyclase.

Packaging

5, 25 mg in glass bottle