Phenamil methanesulfonate salt, solid

Not available outside of the UK & Ireland.

Application

Phenamil methanesulfonate salt has been used: to stimulate adipocyte differentiation in 3T3 cells to test its effect on lateral flagella expression in Vibrio shiloniiin nanoparticle preparation to test its effect on osteo/odontoblastic differentiation

Biochem/physiol Actions

Phenamil is an inducer of peroxisome proliferator-activated receptor γ (PPARγ) and inhibits diamine oxidase. By favoring tribbles homolog 3 (Trb3) expression, phenamil holds therapeutic potential to treat pulmonary artery hypertension (PAH) and idiopathic PAH. It is also a bone morphogenetic protein (BMP) activator, which favors osteogenesis and odontogenesis of stem cells.

General description

Phenamil, a derivative of amiloride is an inhibitor of sodium channels including acid sensing ion channel (ASIC) and epithelial sodium channels (ENaC).

Packaging

5, 25 mg in glass bottle