FK866 hydrochloride hydrate, >=98% (HPLC)

Not available outside of the UK & Ireland.

Application

FK866 hydrochloride hydrate has been used:to investigate its effects on intra-axonal NAD⁺ levelsto induce NAD+ depletionto reduce the level of tumor necrosis factor-α (TNF-α), nicotinamide phosphoribosyltransferase (NAMPT) and interleukin-6 (IL-6) in the ischemic brain tissue

Biochem/physiol Actions

FK866 is a potent inhibitor of NAD biosynthesis, and a specific inhibitor of NAMPT (Nicotinamide Phosphoribosyltransferase, visfatin, PBEF). NAMPT functions as an intra-cellular and extra-cellular NAD biosynthetic enzyme that is important for regulating metabolism and stress resistance through sirtuins and other NAD-consuming regulators. NAMPT also acts as a cytokine independent of its enzymatic activity, playing a major part in regulating immune responses.

General description

FK866 is used to treat inflammatory diseases and cancer.

Packaging

5, 25 mg in glass bottle