Rp-Adenosine 3,5-cyclic monophosphorothioate triethylammonium salt, powder, >=98% (HPLC)

Name: Rp-Adenosine 3,5-cyclic monophosphorothioate triethylammonium salt, powder, >=98% (HPLC)
Brand: SIGMA-ALDRICH
SKU: a165-10mg
Price: 1359.66 USD

Code: a165-10mg D2-231

Not available outside of the UK & Ireland.

Application

Rp-Adenosine 3′,5′-cyclic monophosphorothioate triethylammonium salt has been used as an antagonist of cAMP to block the cAMP-PKA signal pathway.

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OVERVIEW

SPECIFICATIONS

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ATTRIBUTES

Not available outside of the UK & Ireland.
Application
Rp-Adenosine 3′,5′-cyclic monophosphorothioate triethylammonium salt has been used as an antagonist of cAMP to block the cAMP-PKA signal pathway.
Biochem/physiol Actions
Rp-Diastereomer of adenosine-3′,5′-cyclic monophosphothioate. Specific membrane-permeable inhibitor of activation by cAMP of cAMP-dependent protein kinase I and II; resistant toward cyclic nucleotide phosphodiesterases; blocks cAMP-mediated effects in numerous systems.
Rp-Adenosine 3′,5′-cyclic monophosphorothioate triethylammonium salt is capable of inhibiting protein kinase A (PKA).
Caution
Extremely hygroscopic. Store desiccated.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Packaging
1, 5, 10 mg in glass bottle

λ_max 258 nm
assay ≥98% (HPLC)
color white to beige
form powder
InChI key OXIPZMKSNMRTIV-NVGWRVNNSA-N
InChI 1S/C10H12N5O5PS.C6H15N/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(19-10)1-18-21(17,22)20-7;1-4-7(5-2)6-3/h2-4,6-7,10,16H,1H2,(H,17,22)(H2,11,12,13);4-6H2,1-3H3/t4-,6-,7-,10-,21?;/m1./s1
Quality Level 100
SMILES string CCN(CC)CC.Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP(O)(=S)O[C@H]4[C@H]3O
solubility H₂O: 10 mg/mL
storage condition desiccated
storage temp. −20°C

Safety Data Sheet
Safety Data Sheet for A165-10MG
Certificate of Analysis
Sigma Certificate of Analysis

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Cas Number 151837-09-1

This product has met the following criteria to qualify for the following awards:

Rp-Adenosine 3,5-cyclic monophosphorothioate triethylammonium salt, powder, >=98% (HPLC)

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λ_max	258 nm
assay	≥98% (HPLC)
color	white to beige
form	powder
InChI key	OXIPZMKSNMRTIV-NVGWRVNNSA-N
InChI	1S/C10H12N5O5PS.C6H15N/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(19-10)1-18-21(17,22)20-7;1-4-7(5-2)6-3/h2-4,6-7,10,16H,1H2,(H,17,22)(H2,11,12,13);4-6H2,1-3H3/t4-,6-,7-,10-,21?;/m1./s1
Quality Level	100
SMILES string	CCN(CC)CC.Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP(O)(=S)O[C@H]4[C@H]3O
solubility	H₂O: 10 mg/mL
storage condition	desiccated
storage temp.	−20°C