Monoclonal anti-prdx6

Not available outside of the UK & Ireland.

Biochem/physiol Actions

Peroxiredoxin 6 (Prdx6) is a bifunctional enzyme, carrying out both phospholipase A2 (PLA2) activity and glutathione (GSH) peroxidase function. The encoded protein aids in redox regulation of the cell and is implicated in reduction of H₂O₂ and short chain organic, fatty acid, and phospholipid hydroperoxides. It might also have a crucial role in the regulation of phospholipid turnover and in antioxidant defense. Prdx6 is highly expressed at leading edges of wounds and aids in wound healing. Deficiency of the enzyme activity is observed in cataracts of the lens. Overexpression of Prdx6 leads to several degenerative CNS (central nervous system) disorders such as Alzheimer′s, Parkinson′s, Pick′s, and Crutzfeld-Jakob diseases and schizophrenia. In addition, elevated expression of the enzyme is also observed in various neoplastic diseases including malignant mesothelioma, bronchogenic squamous cell carcinoma and cancer of the gingivo-buccal area, bladder and breast.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Peroxiredoxin 6 (Prdx6) is a non-seleno peroxidase enzyme, encoded by the gene mapped to human chromosome 1q25.1. Prdx6 belongs to thiol-specific antioxidant protein family. It is highly expressed in lung, alveolar epithelial type II cells and alveolar macrophages. The protein is characterized with a single conserved cysteine residue and is called 1-Cys Prdx. Prdx6 contains 224 amino acids.

Immunogen

PRDX6 (AAH35857.1, 1 a.a. ~ 224 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.SequenceMPGGLLLGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPAEKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPVDWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP

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Physical form

Solution in phosphate buffered saline, pH 7.4