Not available outside of the UK & Ireland.
Biochem/physiol Actions
Interleukin 2 (IL2)promotes the development of suppressor T regulatory cells. IL2 plays a crucial role in antitumor immunity. IL2 destabilises adherens junctions, and cytoskeletal reorganization, causing increased endothelial cell permeability.
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General description
Interleukin 2 (IL2)is synthesised by immunoregulatory T helper cells. IL2 consists of three subunits, in which the beta subunit is critical for receptor mediated signalling. IL2 gene is located on human chromosome 4q27.
Immunogen
IL2 (NP_000577, 21 a.a. ~ 153 a.a) recombinant protein.SequenceMAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFSQSIISTLT
Legal Information
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Physical form
Solution in phosphate buffered saline, pH 7.4
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