MONOCLONAL ANTI-ITPR1

Not available outside of the UK & Ireland.

Application

Monoclonal Anti-ITPR1 antibody produced in mouse has been used for Western blotting.

Biochem/physiol Actions

Inositol 1,4,5-trisphosphate receptor, type 1 (ITPR1) takes part in Ca²⁺ signaling on binding to its ligand, inositol 1,4,5-trisphosphate.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

Inositol 1,4,5-trisphosphate receptor, type 1 (ITPR1) is highly expressed in the rat brain and is also seen in the heart. It possesses an inositol-triphosphate binding domain, a channel-forming region and a regulatory region. ITPR1 is composed of 2749 amino acids. The gene ID for the protein is 25262.

Immunogen

Fusion protein amino acids 2680-2749 (cytoplasmic carboxyl terminus) of rat type1 IP3R inositol 1,4,5-triphosphate receptor type 1, Itpr1

Physical form

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

Specificity

Detects ~300 kDa. Does not recognize type 2 or type 3 IP3R′s.