Anti-EXO1, N-Terminal antibody produced in rabbit, approx. 1 mg/mL, affinity isolated antibody, buffered aqueous solution

Not available outside of the UK & Ireland.

Application

Anti-EXO1 antibody produced in rabbit has been used in immunoblotting.

Biochem/physiol Actions

Exonuclease 1 (EXO1) N-domain mediates the DNA binding and the I domain is crucial for magnesium binding. It displays micro-mediated end-joining, 5′ to 3′ exonuclease activity and mediates homologous recombination and replication. EXO1 is more efficient on single-stranded DNA (ssDNA) than double-stranded DNA in exonucleolytic degradation. It also exhibits 5′ ssDNA-flap-specific endonuclease activity. EXO1 polymorphismsmay be implicated in epithelial ovarian cancer (EOC).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

Exonuclease 1 (EXO1), a member of RAD2 nuclease family, comprises an amino-terminal (N) domain, intermediate spacer region and an internal (I) domain with cysteine and glutamate residues. The Exo 1 gene is mapped to human chromosome 1q43.

Anti-EXO1 Antibody detects endogenous levels of total EXO1 protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human EXO1.Immunogen Range: 61-110

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.