Anti-Claudin 2, C-Terminal antibody produced in rabbit, approx. 1 mg/mL, affinity isolated antibody, buffered aqueous solution

Not available outside of the UK & Ireland.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.Immunohistochemistry (1 paper)

Biochem/physiol Actions

The tetraspan membrane protein encoded by claudin multigene controls paracellular permeability and maintaining cell polarity in epithelial and endothelial cell sheets. In MDCK (madin-darby canine kidney cells) II cells, claudin-2 participates in the generation of aqueous pores with high conductance.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

Anti-Claudin 2 Antibody detects endogenous levels of total Claudin 2 protein.

Claudin-2 is one of the pore-forming claudins. It is a member of the claudin family of proteins. Claudin-2 is present in the proximal tubules. It is mapped to human chromosome Xq22.

Immunogen

The antiserum was produced against synthesized peptide derived from human Claudin 2.Immunogen Range: 181-230

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.