Anti-MRPL12 antibody produced in rabbit, approx. 1 mg/mL, affinity isolated antibody, buffered aqueous solution

Not available outside of the UK & Ireland.

Application

Anti-MRPL12 antibody produced in rabbit is suitable for capture ELISA and westen blot.

Biochem/physiol Actions

MRPL12 (mitochondrial ribosomal protein) is involved in the mitochondrial translation. It directly interacts with the mitochondrial RNA polymerase (POLRMT) and triggers the mitochondrial transcriptional process. Research shows that the interaction between MRPL12 and POLRMT indicates its participation in the regulatory mechanism that coordinates mitochondrial transcription with translation and/or ribosome biogenesis during human mitochondrial gene expression. Study shows that MRPL12 may be involved in the differentiation of colonic epithelial cells and its reduced mitochondrial activity have been shown to be linked with tumor formation. It has been reported that mutated expression of MRPL12 associates with the growth retardation, neurological deterioration and mitochondrial translation deficiency.

Features and Benefits

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General description

Anti-MRPL12 Antibody detects endogenous levels of total MRPL12 protein.

MRPL12 (mitochondrial ribosomal protein L12) encodes a 21kDa subunit of mitochondrial ribosome. The protein is mapped on chromosome 17 (q25-qter). It is highly expressed in the colon.

Immunogen

The antiserum was produced against synthesized peptide derived from human MRPL12.Immunogen Range: 31-80

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.