Monoclonal Anti-Periostin antibody produced in mouse, approx. 1.0 mg/mL, clone 47, purified immunoglobulin

Not available outside of the UK & Ireland.

Application

Monoclonal Anti-Periostin antibody produced in mouse has been used to develop a periostin imaging PET probe.

Biochem/physiol Actions

Periostin (POSTN) has a role in the differentiation and cell adhesion of osteogenic cells. It functions as a biomarker of T-helper cells type 2-mediated inflammatory diseases. The protein has been associated with various cancers. POSTN is involved in epithelial-mesenchymal transition and extracellular matrix degradation.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Periostin (POSTN) is also known as osteoblast-specific factor-2. It is a 90kDa protein expressed in the extracellular matrix and bones. POSTN is an adhesive glycoprotein. The gene encoding this protein is localized on human chromosome 13q13.3.

Immunogen

human Periostin recombinant protein. The human protein shares 87% homology with the mouse protein.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.