Anti-ZIP14 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution

Not available outside of the UK & Ireland.

Application

Anti-ZIP14 antibody produced in rabbit has been used in immunoblotting. 1:2500

Biochem/physiol Actions

Zrt- and Irt-like protein 14 (ZIP14) is a divalent metal transporter specific for zinc (Zn). However, some studies report, it also mediates the transport of manganese (Mn), iron (Fe), and cadmium (Cd). ZIP14 along with ZIP8 are prime Mn²⁺importers of the brain′s capillary bed and in human brain microvascular endothelial cells (HBMVEC) in in vitro conditions. Mutations in the ZIP14 gene lead to manganese dyshomeostasis, which in turn results in manganeseaccumulation in childhood-onset parkinsonism–dystonia patients.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

Solute carrier family 39 member 14 or Zrt- and Irt-like protein 14 (ZIP14), a transmembrane metal ion transporter, is a member of the LIV-1 subfamily. It contains eight transmembrane domains (TMDs), a metalloprotease, and a histidine-rich motif. ZIP14 is majorly expressed in the pancreas, liver, and heart. The ZIP14 gene is mapped to human chromosome 8p21.3.

Immunogen

ZIP14 antibody was raised against a 16 amino acid peptide near the center of human ZIP14.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500603.

Physical form

Supplied in PBS with 0.02% sodium azide.