ANTI-FOXP3/SCURFIN

Not available outside of the UK & Ireland.

Biochem/physiol Actions

Forkhead box P3 (FOXP3) associates with nuclear factor of activated T cells (NFAT) and nuclear factor κ B (NF-κB). It has a crucial role in the cellular differentiation of regulatory T cells. Alterations in the protein expression have been associated with immunodysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. FOXP3 has a role in tumor growth and cancer.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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General description

Forkhead box P3 (FOXP3) is a transcription factor and part of the forkhead family. It possesses three α helices and three β strands. The protein has an amino-terminal region, a central zinc finger, a leucine zipper domain and the carboxyl-terminal region has a forkhead domain. The gene encoding this protein is localized on human chromosome Xp11.23.

Immunogen

Peptide with sequence SQRPSRCSNPTPGP from the C Terminus of the protein sequence according to NP_054728.2.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.