Anti-CCL4 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution

Not available outside of the UK & Ireland.

Biochem/physiol Actions

MIP-1α and MIP-1β (macrophage inflammatory proteins-1α and β) participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and natural killer (NK) cells. While both MIP-1α and MIP-1β exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1α selectively attracting CD8⁺ lymphocytes and MIP-1β (also known as C-C motif chemokine ligand 4) selectively attracting CD4⁺ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Both MIP-1α and MIP-1β (macrophage inflammatory proteins-1α and β) are structurally and functionally related CC chemokines. They are secreted by activated human monocytes and peripheral blood lymphocytes. The gene encoding this protein is localized on human chromosome 17q12.

Immunogen

CCL4 (NP_002975.1, 1 a.a. ~ 92 a.a) full-length human protein.SequenceMKLCVTVLSLLMLVAAFCSLALSAPMGSDPPTACCFSYTARKLPRNFVVDYYETSSLCSQPAVVFQTKRSKQVCADPSESWVQEYVYDLELN

Physical form

Solution in phosphate buffered saline, pH 7.4