Anti-RNF168 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution

Not available outside of the UK & Ireland.

Biochem/physiol Actions

Ring finger protein 168 (RNF168) plays a vital role in chromatin modification by stimulating histone ubiquitination. In addition, it also initiates DNA damage response to double-strand breaks (DSBs). Mutation in the gene leads to RIDDLE (radiosensitivity, immunodeficiency, dysmorphic features and learning difficulties) syndrome.

Disclaimer

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General description

Ring finger protein 168 (RNF168) is a novel chromatin-associated ubiquitin ligase, encoded by the gene mapped to human chromosome 3q29. RNF168 is characterized with a RING(really interesting new gene) domain and two motifs interacting with ubiquitin (MIU).

The complex repair response elicited by DNA double-strand breaks (DSBs) includes recruitment of several DNA repair proteins and ubiquitination of H2A-type histones (see MIM 142720). RNF168 is an E3 ubiquitin ligase critical for DSB repair (Stewart et al., 2009 [PubMed 19203578]).

Immunogen

RNF168 (NP_689830.2, 1 a.a. ~ 571 a.a) full-length human protein.SequenceMALPKDAIPSLSECQCGICMEILVEPVTLPCNHTLCKPCFQSTVEKASLCCPFCRRRVSSWTRYHTRRNSLVNVELWTIIQKHYPRECKLRASGQESEEVADDYQPVRLLSKPGELRREYEEEISKVAAERRASEEEENKASEEYIQRLLAEEEEEEKRQAEKRRRAMEEQLKSDEELARKLSIDINNFCEGSISASPLNSRKSDPVTPKSEKKSKNKQRNTGDIQKYLTPKSQFGSASHSEAVQEVRKDSVSKDIDSSDRKSPTGQDTEIEDMPTLSPQISLGVGEQGADSSIESPMPWLCACGAEWYHEGNVKTRPSNHGKELCVLSHERPKTRVPYSKETAVMPCGRTESGCAPTSGVTQTNGNNTGETENEESCLLISKEISKRKNQESSFEAVKDPCFSAKRRKVSPESSPDQEETEINFTQKLIDLEHLLFERHKQEEQDRLLALQLQKEVDKEQMVPNRQKGSPDEYHLRATSSPPDKVLNGQRKNPKDGNFKRQTHTKHPTPERGSRDKNRQVSLKMQLKQSVNRRKMPNSTRDHCKVSKSAHSLQPSISQKSVFQMFQRCTK

Physical form

Solution in phosphate buffered saline, pH 7.4