Monoclonal Anti-INS antibody produced in mouse, clone 7C8, purified immunoglobulin, buffered aqueous solution

Not available outside of the UK & Ireland.

General description

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5′ region and with the IGF2 gene at the 3′ region. (provided by RefSeq)

Immunogen

KLH-conjugated human Proinsulin peptide (NP_000198, 48 a.a. ~ 62 a.a)SequenceCFFYTPKTRREAEDLQ

Physical form

Solution in phosphate buffered saline, pH 7.4