Anti-WDR77 antibody produced in rabbit, whole antiserum, buffered aqueous solution

Not available outside of the UK & Ireland.

Biochem/physiol Actions

WD repeat domain 77 (WDR77) associates with protein arginine methyltransferase 5 (PRMT5) in a methylosome complex and stimulates its histone methyltransferase activity. It also binds to androgen receptors and modulates its target genes in prostate epithelial cells and prostate cancer.

General description

WDR77 is a component of the 20S PRMT5 (MIM 604045)-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins (see MIM 601061). This modification targets Sm proteins to the survival of motor neurons (SMN) complex (see MIM 600354) for assembly into small nuclear ribonucleoprotein core particles (Friesen et al., 2002 [PubMed 11756452]).[supplied by OMIM

Immunogen

WDR77 (NP_077007.1, 1 a.a. ~ 342 a.a) full-length human protein.SequenceMRKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAPGPASVTE

Physical form

Clear solution