Anti-Haspin GSG2 (center) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution

Not available outside of the UK & Ireland.

General description

Post-translational modifications of conserved N-terminal tail residues in histones regulate many aspects of chromosome activity. Mitotic phosphorylation of H3 Thr 3 occurs in prophase and dephosphorylation during anaphase. Haspin, a dual serine/threonine kinase, plays an important role in regulation of chromosome and spindle function during mitosis and meiosis via its function in phosphorylation of the threonine residue in the third position of histone 3 (Thr3).

Immunogen

HASPIN GSG2 (NP_114171, 320-355)This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the central region of human haspin.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.