ANTI-MEKK3 (N-TERM)

Not available outside of the UK & Ireland.

General description

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MEKK3 preferentially activates p42/44 (ERK2/ERK1) MAP kinases.

Immunogen

MEKK3 (Q99759, 114-151)This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human MEKK3.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.