Monoclonal Anti-Sodium Channel, Pan antibody produced in mouse, approx. 1 mg/mL, clone K58/35, purified immunoglobulin

Not available outside of the UK & Ireland.

Application

Monoclonal Anti-Sodium Channel, Pan antibody produced in mouse has been used in:immunohistochemistry(1:50)immunostaining (1:200)immunofluorescenceimmunocytochemistry (1:100)

Biochem/physiol Actions

Voltage-gated sodium channels/VGSCs (Nav) participates in nociceptive transmission. They play a key role in regulating the exchange between the extracellular and intracellular spaces. VGSCs are crucial for the initiation and firing of action potentials. They participate in neuronal excitability. Hence mutations in the VGSC genes results in several epileptic disorders.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Voltage-gated sodium channels/VGSCs (Nav) are transmembrane proteins that are initiated by the depolarization of the membrane. They are heteromultimers with large pore-forming α-subunits and smaller β-subunits.

Immunogen

synthetic peptide CTEEQKKYYNAMKKLGSKK from the intracellular III-IV loop of Na⁺ channels

Legal Information

Sold under exclusive license from SUNY Stony Brook.

Physical form

Solution in 10 mM Tris, pH 7.5, containing 0.1 m NaCl, 30% glycerol, and 15 mM sodium azide.

Specificity

The sequence recognized by this clone is identical in all known vertebrate Na⁺ channels. In cultured hippocampal neurons, the antibody specifically stains the axon initial segment. In sciatic and optic nerves, it stains the nodes of Ranvier.