Anti-sec23

Not available outside of the UK & Ireland.

Application

Anti-Sec23 antibody has been used in immunoblotting, in western blot analysis, immunofluorescence.

Biochem/physiol Actions

Sec23A (Sec23 homolog A) plays an important role in protein trafficking between the endoplasmic reticulum and Golgi apparatus. It also participates in anti-tumorigenesis. Suppressing the expression of Sec23A induces multiplication, migration, and invasion of CRC cells (colorectal cancer). Mutation in SEC23A gene results in cranio-lenticulo-sutural dysplasia.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Sec23A (Sec23 homolog A) is a human Sec23 paralog, that is a GTPase-activating protein. It is a fundamental constituent of the coat protein II complex. It is located on human chromosome 14q21.

Sec23 has two isoforms, Sec23A and Sec23B. Sec23A is mainly found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles.

Immunogen

synthetic peptide corresponding to amino acid residues 1-18 of human Sec23A with C-terminal added cysteine conjugated to KLH. The corresponding sequence is identical in rat and mouse Sec23A and differs by one amino acid in human and mouse Sec23B.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.