Monoclonal Anti-Na+/Ca2+ Exchanger antibody produced in mouse, clone C2C12, ascites fluid

Not available outside of the UK & Ireland.

Biochem/physiol Actions

Na⁺/Ca²⁺ exchanger (SLC8A1, solute carrier family 8 member A1) is involved in Ca²⁺ homeostasis. Depending on physiological conditions prevailing in the cell, it can either pump out Na⁺ or Ca²⁺.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Na⁺/Ca²⁺ exchanger is also known as solute carrier family 8 member A1 (SLC8A1) and is present in the plasma membrane. It is predicted to have nine transmembrane segments and the gene encoding SLC8A1 has three promoters.

Immunogen

dog cardiac Na⁺/Ca²⁺ exchanger. The epitope is in the region of amino acids 371-525, which is on the intracellular side of the plasma membrane.

Physical form

Solution in phosphate buffered saline, 1 mg/ml BSA containing 0.05% sodium azide.

Specificity

The antibody reacts specifically with Na⁺/Ca²⁺ exchanger in kidney and cardiac tissues. By immunohistology, staining of the plasma membrane and intense staining of the cardiac T-tubular membrane is observed. The antibody is not recommended for immunoblotting of rat tissues.