Goat anti-human interleukin 11

Not available outside of the UK & Ireland.

Application

Anti-Human IL-11 is suitable for neutralization reactions.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Interleukin-11 (IL-11) is a pleotropic cytokine that belongs to the IL-6 family. The effects of IL-11 include hemopoiesis, macrophage differentiation and thrombopoiesis. Many cell types including osteoblasts, trophoblasts, fibroblasts, chondrocytes and a variety of tissue such as brain, gut, spinal cord and testis secrete IL-11. The cellular effects of IL-11 are mediated by a multimeric complex consisting of IL-11Rα and gp130Rβ subunits. The pathways activated by IL-11 include JAK/STAT, Ras/MAPK and Grb2 signaling. IL-11 plays a major role in inflammatory responses, immune responses by regulating the production of IgG by B cells and in tumorigenesis-related inflammation Anti-Interleukin-11 antibody specifically reacts with human IL-11.

Immunogen

recombinant human IL-11 expressed in Sf 21 insect cells.

Physical form

Lyophilized from a 0.2 µm filtered solution in phosphate buffered saline.

Preparation Note

Purified using protein G.

Specificity

The antibody neutralizes the biological activity of recombinant human IL-11.