Anti-interleukin-8

Not available outside of the UK & Ireland.

Application

Anti-Interleukin-8 antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Interleukin-8 (IL 8) is a proinflammatory chemokine that activates multiple signaling pathways. The exosomes released from chronic myelogenous leukemia (CML) cells stimulate bone marrow stromal cells to produce IL 8. It plays a very important regulatory function in tumorigenesis. Its polymorphism is associated with a significantly increased risk of cancers and may be useful for cancer susceptibility studies.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

IL-8 (interleukin-8), also called CXCL8, is an α chemokine belonging to the cysteine-x-cysteine (CXC) chemokine subfamily. It is a pro-inflammatory cytokine and is secreted by multiple types of tissues and blood cells such as, monocytes, neutrophils, tissue macrophages, T-lymphocytes, endothelial and epithelial cells, and fibroblasts. It is pro-angiogenic and tumorigenic, and is produced by cancer cells such as, colorectal cancer cells.

Immunogen

Immunogen Sequence: GI # 124359, sequence 28-99

Recombinant interleukin-8

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.