Monoclonal Anti-Bone Morphogenetic Protein 2 antibody produced in mouse, clone 65529.111, purified immunoglobulin, lyophilized powder

Not available outside of the UK & Ireland.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.Immunohistochemistry (1 paper)

Monoclonal Anti-BMP-2 antibody may be used in immunoblotting at a working antibody concentration of 1-2 µg/ml.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Bone morphogenetic proteins (BMPs) are the members of the TGF-β superfamily and are identified as the critical factors for formation of bone and cartilage. Apart from this BMPs have immune regulatory functions. The cellular effects of BMPs are mediated by a heteromeric complex composed of type I and type II receptors. Among the BMPs, BMP-2 has bone and cartilage inducing abilities. The other important functions of BMP-2 are in heart formation. BMP-2 signaling also involves active cross talk with major pathways such as Smad, MAPK, PI3K and NF-κ B.. Monoclonal Anti-BMP-2 recognizes recombinant BMP-2. It also detects BMP-4 (25% cross reactivity).

Immunogen

recombinant human BMP-2.

Physical form

Lyophilizd from a 0.2 µm filtered solution in PBS, pH 7.4, with 5% trehalose.

Preparation Note

Purified using protein G.

Specificity

The antibody recognizes recombinant human BMP-2. It shows approximately 25% cross-reactivity with recombinant human BMP-4.