Anti-Potassium Channel KCNQ5

Not available outside of the UK & Ireland.

Application

Western Blotting Analysis: A 0.1µg/mL dilution from a representative lot detected Potassium Channel KCNQ5 in 10 µg of transient over-expression of Potassium Channel KCNQ5 in HEK293 cell lysate.

Research CategoryNeuroscience

This Anti-Potassium Channel KCNQ5 Antibody is validated for use in Immunohistochemistry and Western Blotting for the detection of Potassium Channel KCNQ5.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

KCNQ5 is subunit one of a voltage gated potassium channel expressed in the brain and other tissues. KCNQ5 forms the complete channel with KCNQ3. This channel gives rise to the "M" potassium current which is a slowly activating and deactivating current. This current plays a critical role in determining the subthreshold electrical excitability of neurons. KCNQ5 is strongly expressed in the brain but also in skeletal muscle and vascular smooth muscle cells. KCNQ5 activity is also regulated via phosphorylation by PKC and that kinase regulation may be a key to regulating excitability in neurons and muscle cells.

Immunogen

KLH-conjugated linear peptide corresponding to the Human Potassium Channel KCNQ5.

Linkage

Replaces: AB5599

Other Notes

Concentration: Please refer to lot specific datasheet.

Physical form

Purified rabbit Polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Antigen Affinity Purified

Quality

Evaluated by Immunohistochemistry in human cerebral cortex tissue.

Imunnohistochemistry Analysis: A 1:2,000 dilution of this antibody detected Potassium Channel KCNQ5 in human cerebral cortex tissue.

Specificity

Western Blotting Analysis was tested on overxpressing transfected cell lysate.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~103 kDa observed. Predicted to cross react to Isoforms 1, 2, and 3. Additional bands are detected in endogenous lysates.