Anti-MYOD1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution

Not available outside of the UK & Ireland.

Biochem/physiol Actions

Myogenic differentiation 1 (MYOD1) associates with histone-modifying enzymes and stimulates muscle differentiation by elevating the expression of histone H3 mono methyl K4 (H3K4me1) and histone H3 acetyl 27 (H3K27ac). MyoD1 staining can be considered as a key adjunct in the sorting of pediatric soft-tissue sarcomas. Mutation in the gene is associated with the pathogenesis of perinatally lethal fetal akinesia.

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General description

Myogenic differentiation 1 (MYOD1) is encoded by the gene mapped to human chromosome 11p15.1. The encoded protein belongs to the basic helix-loop-helix (bHLH) family of transcription factors. MYOD1 is expressed exclusively during normal skeletal muscle myogenesis and in rhabdomyosarcomas.

Immunogen

MYOD1 (NP_002469.2, 1 a.a. ~ 320 a.a) full-length human protein.SequenceMELLSPPLRDVDLTAPDGSLCSFATTDDFYDDPCFDSPDLRFFEDLDPRLMHVGALLKPEEHSHFPAAVHPAPGAREDEHVRAPSGHHQAGRCLLWACKACKRKTTNADRRKAATMRERRRLSKVNEAFETLKRCTSSNPNQRLPKVEILRNAIRYIEGLQALLRDQDAAPPGAAAAFYAPGPLPPGRGGEHYSGDSDASSPRSNCSDGMMDYSGPPSGARRRNCYEGAYYNEAPSEPRPGKSAAVSSLDCLSSIVERISTESPAAPALLLADVPSESPPRRQEAAAPSEGESSGDPTQSPDAAPQCPAGANPNPIYQVL

Physical form

Solution in phosphate buffered saline, pH 7.4