Not available outside of the UK & Ireland.
Application
Peroxynitrite has been used to induce pericyte contraction in mouse brains. It has also been used for the preparation of positive control nitrated protein standards in immunohistochemical studies.
Biochem/physiol Actions
Peroxynitrite (ONOO−) exhibits bactericidal activity. It promotes cell death and contributes to the signal-transduction process, mitochondrial function, and apoptotic pathway. The formation of peroxynitrite has been associated with the development of various diseases including vascular diseases, ischemia-reperfusion injury, circulatory shock, inflammation, pain, and neurodegeneration.
General description
Peroxynitrite (ONOO−) is a powerful oxidant formed by the collision of nitric oxide and superoxide.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Physical form
0.3M NaOH
Quality
Routinely evaluated by treating non-stimulated A431 cells.
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