Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
Potent inhibitor of CDK5/p25 (IC50=64 nM). Inhibits CDK2/cyclin E at slightly higher concentration (IC50=98nM) (1). Protects cells against NAC-amyloid-induced cell death (2). Cell permeable. MW=260.4. Purity ?95% by TLC. Formulated as a lyophilized powder. May be dissolved in DMSO (>25 mg/mL) or DMF (30 mg/mL). Stable desicated as supplied at ambient temperature for up to 2 years, or in solution at -20°C for up to 2 months.
Storage and Stability
Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 2 months.
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :