GT949

Code: sml2823-5mg D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

GT949 is a potent and selective positive allosteric modulator (PAM) of the excitatory amino acid transporter EAAT2 (glutamate uptake EC50 =...


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$99.35 EACH
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Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

GT949 is a potent and selective positive allosteric modulator (PAM) of the excitatory amino acid transporter EAAT2 (glutamate uptake EC50 = 0.26 nM; COS-7 EAAT2 transfectant), but not EAAT1 or EAAT3. GT949 enhances glutamate uptake of cultured rat astrocytes (EC50 = 1 nM, Emax = 158%) with no potency toward human serotonin (SERT), noradrenaline (NET) and dopamine (DAT) transporters, nor NMDA receptors (murine primary cortical neurons).

assay≥98% (HPLC)
colorwhite to beige
formpowder
Quality Level100
SMILES stringO=C1C(C(C2=NN=NN2CCC3=CC=CC=C3)N4CCN(CC4)C5CCCCC5)=CC6=CC(OC)=CC=C6N1
solubilityDMSO: 2 mg/mL, clear
storage temp.2-8°C
Cas Number460330-27-2
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