D-I03

Code: sml2496-25mg D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

D-I03 is a selective RAD52 inhibitor (IC50 = 5 and 8 µM, respectively, by SSA and DNA pairing (D-loop formation) assay; ﹤5% RAD51 inhibiti...


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$435.51 25MG

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

D-I03 is a selective RAD52 inhibitor (IC50 = 5 and 8 µM, respectively, by SSA and DNA pairing (D-loop formation) assay; ﹤5% RAD51 inhibition at 80 µM) that blocks single-strand DNA (ssDNA) annealing (SSA)-, but not homology dependent recombination (HDR)-, mediated double-strand break (DSB) repair (5-30 µM using respective U2OS reporter cells) and reduces nuclear RAD52, but not RAD51, foci formation (2.5 µM) upon DNA damage by cisplatin. D-I03 selectively suppresses BRCA1-deficient over BRCA1-proficient cancer cells and exerts synergistic activity with PARP1 inhibitors against BRCA1-deficient cancer both in cultures (1 & 2.5 µM) and in mice (50 mg/kg/day i.p.) in vivo.

assay≥98% (HPLC)
colorwhite to beige
formpowder
SMILES stringS=C(NCCN(CC)CC)NC1=CC2=C(C=C1)N=C(N3CCN(CC)CC3)C=C2C
solubilityDMSO: 2 mg/mL, clear
storage temp.2-8°C
Cas Number688342-78-1
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :



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