ML348

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

ML348 is a substrate-competitive, reversible and APT1-selective acyl-protein thioesterase (APT) inhibitor (IC₅₀/Ki = 840 nM/300 nM against APT1; IC₅₀ & Ki >10 µM against APT2). ML348 effectively inhibits cellular APT1 activity in cultures (by >95% in HEK293T & mouse T cells; 5 µM for 4 h) and in mice in vivo (by >90% in lung/heart/kidney and by ~50% in brain tissue 4 h post 50 mg/kg i.p. dosing) without affecting more than 15 cellular serine hydrolases and APT2.

Packaging

5, 25 mg in glass bottle