PB28 dihydrochloride, >=98% (HPLC), solid

Name: PB28 dihydrochloride, >=98% (HPLC), solid
Brand: SIGMA-ALDRICH
SKU: P9246-5MG
Price: 150.76 USD

Code: P9246-5MG D2-231

Not available outside of the UK & Ireland.

Application

PB28 dihydrochloride has been used to test its inhibitory effect on potassium voltage-gated channel, shab-related subfamily, member 1, Kv2.1.

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$150.76 5MG

Discontinued

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Not available outside of the UK & Ireland.
Application
PB28 dihydrochloride has been used to test its inhibitory effect on potassium voltage-gated channel, shab-related subfamily, member 1, Kv2.1.
Biochem/physiol Actions
Selective σ₂opioid receptor ligand; putative σ₂ agonist
PB28, a cyclohexylpiperazine derivative, is a sigma 1 (σ1)-R antagonist. It elicits anti-tumor activity in breast, ovarian and colorectal cancer cell lines.

assay ≥98% (HPLC)
color white
form solid
InChI key DSRBJOQIBXACIV-UHFFFAOYSA-N
InChI 1S/C24H38N2O.2ClH/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21;;/h6,12,14,20-21H,2-5,7-11,13,15-19H2,1H3;2*1H
Quality Level 100
SMILES string Cl[H].Cl[H].COc1cccc2C(CCCN3CCN(CC3)C4CCCCC4)CCCc12
solubility H₂O: ~10 mg/mL at 60 °C
storage condition desiccated

Safety Data Sheet
Safety Data Sheet for P9246-5MG
Certificate of Analysis
Sigma Certificate of Analysis

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Cas Number 172906-90-0

This product has met the following criteria to qualify for the following awards:

PB28 dihydrochloride, >=98% (HPLC), solid

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assay	≥98% (HPLC)
color	white
form	solid
InChI key	DSRBJOQIBXACIV-UHFFFAOYSA-N
InChI	1S/C24H38N2O.2ClH/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21;;/h6,12,14,20-21H,2-5,7-11,13,15-19H2,1H3;2*1H
Quality Level	100
SMILES string	Cl[H].Cl[H].COc1cccc2C(CCCN3CCN(CC3)C4CCCCC4)CCCc12
solubility	H₂O: ~10 mg/mL at 60 °C
storage condition	desiccated