Concanamycine a, > = 70% (HPLC)

Code: C9705-25UG D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Concanamycin A has been used: as a lysosomal inhibitor in young and old fibroblasts as a vacuolar-type H+-ATPase inhibitor in presynaptic vesiclesas a ...


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$335.20 25UG
DEMANDER

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Concanamycin A has been used: as a lysosomal inhibitor in young and old fibroblasts as a vacuolar-type H+-ATPase inhibitor in presynaptic vesiclesas a lysosomal acidification blocker in HepG2 hepatocytes cells

Biochem/physiol Actions

Concanamycin A (ConA) inhibits acidification of organelles and perforin-mediated cytotoxicity. It is a vacuolar-type v-ATPase inhibitor. ConA possesses antiprotozoal and antineoplastic properties. It mediates inhibition of the negative factor (Nef) protein of the human immunodeficiency virus.

General description

Chemical structure: macrolide

Concanamycin A belongs to the plecomacrolide family and comprises an 18-membered tetraenic macrolide ring.

antibiotic activity spectrumviruses
assay≥70% (HPLC)
formcrystals
InChI keyDJZCTUVALDDONK-LWLXYWDNSA-N
InChI1S/C46H75NO14/c1-13-16-34-28(7)37(58-38-22-33(48)43(31(10)57-38)60-45(47)53)23-46(54,61-34)30(9)41(51)29(8)42-35(55-11)18-15-17-24(3)19-26(5)39(49)32(14-2)40(50)27(6)20-25(4)21-36(56-12)44(52)59-42/h13,15-18,20-21,26-35,37-43,48-51,54H,14,19,22-23H2,1-12H3,(H2,47,53)/b16-13+,18-15+,24-17+,25-20+,36-21-/t26?,27?,28-,29?,30?,31-,32?,33-,34?,35?,37-,38+,39?,40?,41?,42?,43-,46+/m1/s1
mode of actionenzyme | inhibits
Quality Level200
SMILES stringCCC1C(O)C(C)CC(C)=CC=CC(OC)C(OC(=O)C(OC)=CC(C)=CC(C)C1O)C(C)C(O)C(C)[C@]2(O)C[C@@H](O[C@H]3C[C@@H](O)[C@H](OC(N)=O)[C@@H](C)O3)[C@H](C)C(O2)C=CC
storage temp.−20°C
Cas Number80890-47-7
Hazard Class6.1
Un Number3462
Pack GroupII
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