Hypéricine de l'Hypericum perforatum, environ 0,95% (HPLC)

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Hypericin from Hypericum perforatum has been used:in the broth macrodilution test and antibacterial assay against bacterial strainsas a medium supplement for human malignant melanoma cells for irradiation and localization studiesas a ligand for pregnane X receptor (PXR) and as defatting medium supplement for primary human hepatocytes culture

Biochem/physiol Actions

Anthraquinone-derivative within St. John′s wort. Antibacterial effective against Gram-positive and Gram-negative bacteria.

Hypericin is a potent inhibitor of protein kinase C (PKC), telomerase, cytochrome P450 and reverse transcriptase. It is exploited for its photosensitizing functionality in photodynamic therapy (PDT) and photodynamic diagnosis (PDD) in cancer cells.

General description

Hypericin hydrophobic is a red color pigment occurring naturally in Hypericum perforatum. Its fluorescence is measured at 600 nm. It is localized in the intracellular membranes including nuclear membrane, mitochondrial membrane, Golgi apparatus, lysosomes and endoplasmic reticulum.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.