AEBSF, HCl> = 99 % par HPLC 1 pc x 250 MG

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Reversible: no

Primary TargetSerine proteases

General description

Specific irreversible inhibitor of serine proteases. Reacts covalently with a serine at the active site. Inhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. Stable, nontoxic alternative to PMSF (Cat. No. 52332) and DFP (Cat. No. 30967). Used at the same molar concentration (0.1-1.0 mM) as PMSF for most applications. Exhibits low inhibitory activity towards proteinase K. A material with ≥97% purity by HPLC (Cat. No. 101500) & its InSolution™ is also available (Cat. No. 508436).Please note that the molecular weight for this compound is batch-specific due to variable water content.

AEBSF >99%; 30827-99-7

Specific irreversible inhibitor of serine proteases. Reacts covalently with a serine at the active site. Inhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. Stable, nontoxic alternative to PMSF (Cat. No. 52332) and DFP (Cat. No. 30967). Used at the same molar concentration (0.1-1.0 mM) as PMSF for most applications. Exhibits low inhibitory activity towards proteinase K. A material with ≥97% purity by HPLC (Cat. No. 101500) & its InSolution™ is also available (Cat. No. 508436).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Citron, M., et al. 1996. Neuron17, 171.r>Ohkubo, I., et al. 1994. J. Biochem.116, 1182.r>Mintz, G.R. 1993. BioPharm.6, 34.r>Lawson, W.B., et al. 1982. Folia Haematol.109, 52.r>Markwardt, F., et al. 1974. Biochem. Pharmacol.23, 2247.Markwardt, F., et al. 1973. Thromb. Res.2, 343.Baker, B.R., and Cory, M. 1971. J. Med. Chem.14, 119.

Packaging

250 mg in Glass bottle

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Corrosive (L)