Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
Reversible: no
Product does not compete with ATP.
Primary Targetthe expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages
Cell permeable: yes
General description
A sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties. Inhibits the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages. Also inhibits NF-κB and activation of MAP kinase.
A cell-permeable sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties. Inhibits the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages. Also inhibits NF-κB and activation of MAP kinase.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Wong, H.R., et al. 1999. Biochem. Biophys. Res. Comm.262, 375.Bork, P.M., et al. 1997. FEBS Lett. 402, 85.Hwang, D., et al. 1996. Biochem. Biophys. Res. Commun. 226, 810.Barsby, R.W., et al. 1992. J. Pharm. Pharmacol. 44, 737.Sumner, H., et al. 1992. Biochem. Pharmacol. 43, 2313.
Packaging
50 mg in Plastic ampoule
Warning
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :