Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
Primary Targetu opioid receptor
General description
A very potent and highly selective peripheral resctricted µ-opioid receptor agonist (Ki = 2 nM). Often used as an antidiarrheal, antipruritic, and antihyperalgesic agent. In addition, shown to improve defective post-receptor insulin signaling in skeletal muscle cells and enhance insulin sensitivity in rats.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Cheng, K., et al. 2013. Pharmaco. Ther.139, 334.Di Bosco, M., et al. 2008. Chem. Biol. Drug Des.71, 328.DeHaven-Hudkins, D., et al. 1999. J. Pharmacol. Exp. Ther.289, 494.Mackerer, C., et al. 1976. J. Pharmacol. Exp. Ther.199, 131.
Packaging
1 g in Glass bottle
Preparation Note
Warming is required for complete solubilization in ethanol.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Warning
Toxicity: Toxic (F)
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