Non disponible en dehors du Royaume-Uni et de l'Irlande
General description
A blood brain barrier permeable pyrimidinyl-aminothiazole compound that specifically interacts with TACC3 (transforming acidic coiledcoil-containing protein 3) and promotes nuclear localization of ARNT2 (aryl-hydrocarbon receptor nuclear translocator 2). Shown to significantly induce neuronal differentiation of cultured rat hippocampal NPCs (neural progenitor cells; EC50 ~ 1 µM) and in adult rats (6 mg/kg, s.c.) and suppress proliferation.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Wurdak, H., et al. 2010. Proc. Natl. Acad. Sci. USA107, 16542
Packaging
Packaged under inert gas
10 mg in Glass bottle
Warning
Toxicity: Standard Handling (A)
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :