Non disponible en dehors du Royaume-Uni et de l'Irlande
General description
Inhibits thymidylate synthetase, is a nonselective de novo purine synthesis inhibitor and has a significant toxicity profile including hepatotoxicity, pneumonitis and bone marrow suppression. Potent folic acid antagonist. Induces apoptosis in HL-60 human leukemia cells. Also useful as an anti-tumor agent.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Kaufman, S.H., et al. 1993. Cancer Res.53, 3976.Takasuga, A., et al. 1992. J. Biochem.112, 652.Hirata, S., et al. 1989. Arthritis Rheum. 32, 1065.Jolivet, J., et al. 1983. New Engl. J. Med. 309, 1094.
Packaging
100 mg in Glass bottle
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Warning
Toxicity: Toxic (F)
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